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Flavopiridol(Alvocidib)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Flavopiridol(Alvocidib)图片
CAS NO:146426-40-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
HMR-1275, L868275
产品介绍

生物活性

Flavopiridol(Alvocidib)是一种细胞周期蛋白依赖性激酶抑制剂,与ATP竞争性抑制CDK,包括CDK1, CDK2, CDK4和CDK6,CDK9。作用于CDK1, 2, 4, 6,9比作用于CDK7更具有选择性,用于治疗慢性淋巴细胞性白血病。

靶点信息

CDK1CDK2CDK4CDK6CDK7
40 nM40 nM40 nM40 nM300 nM

化学数据

目录号A10390
作用机制Inhibitor (抑制剂)
M. Wt401.8
FormulaC21H20ClNO5
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.146426-40-6
SynonymsHMR-1275, L868275
SMILESCN1CC[C@@H]([C@@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O

溶解度

In vitro (25°C)DMSO14 mg/mL (34.83 mM)
WaterInsoluble
Ethanol7 mg/mL (17.41 mM)
In vivo5% DMSO+30% PEG 300+ddH2O2.3 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM24.89 mL124.44 mL248.88 mL
0.5 mM4.98 mL24.89 mL49.78 mL
1 mM2.49 mL12.44 mL24.89 mL
5 mM0.5 mL2.49 mL4.98 mL

*The above data is based on the productmolecular weight 401.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.