FK-506(Tacrolimus)

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FK-506(Tacrolimus)

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

104987-11-3

包装与价格：

包装	价格(元)
50mg	电议
100mg	电议
500mg	电议
10mM * 1mL in DMSO	电议

产品名称

FK506, Fujimycin, Prograf , Tacrolimus

产品介绍

生物活性

FK-506 (Tacrolimus)是一种免疫抑制药物，通过结合到抑免蛋白FKBP12 (FK506 结合蛋白)产生新的复合物，从而降低T细胞中肽酰脯氨酰异构酶活性。

靶点信息

FKBP12 (T cells)

化学数据

目录号	A10389
作用机制	Inhibitor (抑制剂)
M. Wt	804
Formula	C44H69NO12
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	104987-11-3
Synonyms	FK506, Fujimycin, Prograf , Tacrolimus
SMILES	C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC

溶解度

In vitro (25°C)	DMSO	81 mg/mL (100.74 mM)
	Water	Insoluble
	Ethanol	71 mg/mL (88.31 mM)
In vivo	5% DMSO+corn oil	14 mg/mL
<1 mg/ml means slightly soluble or insoluble. Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	12.44 mL	62.19 mL	124.38 mL
0.5 mM	2.49 mL	12.44 mL	24.88 mL
1 mM	1.24 mL	6.22 mL	12.44 mL
5 mM	0.25 mL	1.24 mL	2.49 mL

*The above data is based on the productmolecular weight 804. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.