生物活性
Exemestane是一种口服类固醇芳香化酶抑制剂,除绝经后妇女的手术和/或放疗外,还用于ER阳性乳腺癌。
靶点信息
Aromatase (human) | Aromatase (rat) | | | |
30 nM | 40 nM | | | |
化学数据
目录号 | A10378 |
作用机制 | Inhibitor (抑制剂) |
M. Wt | 296.4 |
Formula | C20H24O2 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 107868-30-4 |
Synonyms | Aromasin |
SMILES | C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CC(=C)C4=CC(=O)C=C[C@]34C |
溶解度
In vitro | DMSO | 52 mg/mL (175.43 mM) |
Water | Insoluble |
Ethanol | 15 mg/mL (50.6 mM) |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 33.74 mL | 168.69 mL | 337.38 mL |
0.5 mM | 6.75 mL | 33.74 mL | 67.48 mL |
1 mM | 3.37 mL | 16.87 mL | 33.74 mL |
5 mM | 0.67 mL | 3.37 mL | 6.75 mL |
*The above data is based on the productmolecular weight 296.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.