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Everolimus(RAD001)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Everolimus(RAD001)图片
CAS NO:159351-69-6
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
SDZ-RAD, Certican, Zortress, Afinitor
产品介绍

生物活性

Everolimus (RAD001)是西罗莫司的40-O-(2-羟乙基)衍生物,与西罗莫司作为mTOR抑制剂的作用相似。

靶点信息

mTOR (FKBP12) (Cell-free assay)
1.6 nM-2.4 nM

化学数据

目录号A10374
作用机制Inhibitor (抑制剂)
M. Wt958.2
FormulaC53H83NO14
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.159351-69-6
SynonymsSDZ-RAD, Certican, Zortress, Afinitor
SMILESC[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OCCO)C)/C)O)OC)C)C)/C)OC

溶解度

In vitro (25°C)DMSO91 mg/mL (94.97 mM)
WaterInsoluble
Ethanol6 mg/mL (6.26 mM)
In vivo30% Propylene glycol (dissolve first)+5% Tween 80+ddH2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM10.44 mL52.18 mL104.36 mL
0.5 mM2.09 mL10.44 mL20.87 mL
1 mM1.04 mL5.22 mL10.44 mL
5 mM0.21 mL1.04 mL2.09 mL

*The above data is based on the productmolecular weight 958.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.