Everolimus(RAD001)

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Everolimus(RAD001)

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

159351-69-6

包装与价格：

包装	价格(元)
10mg	电议
50mg	电议
100mg	电议
10mM * 1mL in DMSO	电议

产品名称

SDZ-RAD, Certican, Zortress, Afinitor

产品介绍

生物活性

Everolimus (RAD001)是西罗莫司的40-O-(2-羟乙基)衍生物，与西罗莫司作为mTOR抑制剂的作用相似。

靶点信息

mTOR (FKBP12) (Cell-free assay)
1.6 nM-2.4 nM

化学数据

目录号	A10374
作用机制	Inhibitor (抑制剂)
M. Wt	958.2
Formula	C53H83NO14
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	159351-69-6
Synonyms	SDZ-RAD, Certican, Zortress, Afinitor
SMILES	C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OCCO)C)/C)O)OC)C)C)/C)OC

溶解度

In vitro (25°C)	DMSO	91 mg/mL (94.97 mM)
	Water	Insoluble
	Ethanol	6 mg/mL (6.26 mM)
In vivo	30% Propylene glycol (dissolve first)+5% Tween 80+ddH2O	4 mg/mL
<1 mg/ml means slightly soluble or insoluble. Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	10.44 mL	52.18 mL	104.36 mL
0.5 mM	2.09 mL	10.44 mL	20.87 mL
1 mM	1.04 mL	5.22 mL	10.44 mL
5 mM	0.21 mL	1.04 mL	2.09 mL

*The above data is based on the productmolecular weight 958.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.