生物活性
Epothilone B (EPO906)是一种紫杉醇样microtubule稳定剂。
靶点信息
| Tubulin (Cell-free assay) | | | | |
| 1.8 μM(EC0.01) | | | | |
化学数据
| 目录号 | A10360 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 507.7 |
| Formula | C27H41NO6S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 152044-54-7 |
| Synonyms | Patupilone, Epothilone-B |
| SMILES | C[C@H]1CCC[C@@]2([C@@H](O2)C[C@H](OC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C)C |
溶解度
| In vitro (25°C) | DMSO | 93 mg/mL (183.18 mM) |
| Water | Insoluble |
| Ethanol | 93 mg/mL (183.18 mM) |
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 4 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 19.7 mL | 98.48 mL | 196.97 mL |
| 0.5 mM | 3.94 mL | 19.7 mL | 39.39 mL |
| 1 mM | 1.97 mL | 9.85 mL | 19.7 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.94 mL |
*The above data is based on the productmolecular weight 507.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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