生物活性
LY317615(Enzastaurin)是一种有效的,选择性的PKCβ抑制剂,具有抗增殖活性(IC50 =?6 nM)。
靶点信息
PKCβ (Cell-free assay) | PKCα (Cell-free assay) | PKCγ (Cell-free assay) | PKCε (Cell-free assay) | |
6 nM | 39 nM | 83 nM | 110 nM | |
化学数据
目录号 | A10356 |
作用机制 | Inhibitor (抑制剂) |
M. Wt | 515.6 |
Formula | C32H29N5O2 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 170364-57-5 |
Synonyms | LY-317615 |
SMILES | CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)C6CCN(CC6)CC7=CC=CC=N7 |
溶解度
In vitro (25°C) | DMSO | 29 mg/mL (56.24 mM) |
Water | Insoluble |
Ethanol | Insoluble |
In vivo | 15% Captisol | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 19.39 mL | 96.97 mL | 193.95 mL |
0.5 mM | 3.88 mL | 19.39 mL | 38.79 mL |
1 mM | 1.94 mL | 9.7 mL | 19.39 mL |
5 mM | 0.39 mL | 1.94 mL | 3.88 mL |
*The above data is based on the productmolecular weight 515.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.