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E7080(Lenvatinib)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
E7080(Lenvatinib)图片
CAS NO:417716-92-8
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
E-7080
产品介绍

生物活性

E7080 (Lenvatinib)是一种多激酶抑制剂,可同时抑制VEGFR2和VEGFR3激酶。

Targets

TargetValue
VEGFR2/KDRIC50: 4.0nM
VEGFR3/FLT4IC50: 5.2nM
VEGFR1/FLT1IC50: 22nM
PDGFRβIC50: 39nM
FGFR1IC50: 46nM
PDGFRαIC50: 51nM
KitIC50: 100nM
EphB4IC50: >10μM
IGF-1RIC50: >10μM
Insulin ReceptorIC50: >10μM
SrcIC50: >10μM
Akt1IC50: >10μM
CDK4/CyclinDIC50: >10μM
PLK1IC50: >10μM
FAKIC50: >10μM
PKCαIC50: >10μM

化学数据

目录号A10340
作用机制Inhibitor (抑制剂)
M. Wt426.9
FormulaC21H19ClN4O4
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.417716-92-8
SynonymsE-7080
SMILESCOC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl

溶解度

In vitro (25°C)DMSOWarmed: 35 mg/mL (81.99 mM)
WaterInsoluble
EthanolInsoluble
In vivo0.5% methylcellulose28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM23.42 mL117.12 mL234.25 mL
0.5 mM4.68 mL23.42 mL46.85 mL
1 mM2.34 mL11.71 mL23.42 mL
5 mM0.47 mL2.34 mL4.68 mL

*The above data is based on the productmolecular weight 426.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.