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Droxinostat
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Droxinostat图片
CAS NO:99873-43-5
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品介绍

生物活性

Droxinostat是HDAC3,HDAC6和HDAC8的选择性抑制剂,显示出可比较的HDAC6和HDAC8抑制作用,IC50分别为2.47和1.46μmol/ L。

Targets

TargetValue
HDAC8IC50: 1.46μM
HDAC6IC50: 2.47μM
HDAC3IC50: 16.9μM
HDAC9IC50: >20μM
HDAC10IC50: >20μM
HDAC1IC50: >20μM
HDAC2IC50: >20μM
HDAC4IC50: >20μM
HDAC5IC50: >20μM
HDAC7IC50: >20μM

化学数据

目录号A10337
作用机制Inhibitor (抑制剂)
M. Wt243.7
FormulaC11H14ClNO3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.99873-43-5
SMILESCC1=C(C=CC(=C1)Cl)OCCCC(=O)NO

溶解度

In vitro (25°C)DMSO47 mg/mL (192.86 mM)
WaterInsoluble
Ethanol47 mg/mL (192.86 mM)
In vivo30% propylene glycol, 5% Tween 80, 65% D5W28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM41.03 mL205.17 mL410.34 mL
0.5 mM8.21 mL41.03 mL82.07 mL
1 mM4.1 mL20.52 mL41.03 mL
5 mM0.82 mL4.1 mL8.21 mL

*The above data is based on the productmolecular weight 243.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.