生物活性
Daptomycin是一种脂肽抗生素，用于治疗由革兰氏阳性生物体引起的某些感染。
靶点信息
| DNA synthesis (Cell-free assay) | | | | |
| | | | |
化学数据
| 目录号 | A10289 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 1620.7 |
| Formula | C72H101N17O26 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 103060-53-3 |
| Synonyms | Cubicin |
| SMILES | O=C([C@H](CC1=CNC2=CC=CC=C12)NC(CCCCCCCCC)=O)N[C@@H](C(N[C@H](C(N[C@@H]([C@@H](C)OC([C@]([H])(CC(C3=C(N)C=CC=C3)=O)NC([C@]([H])([C@@H](CC(O)=O)C)NC([C@@]([H])(CO)NC(CNC4=O)=O)=O)=O)=O)C(NCC(N[C@@H](CCCN)C(N[C@@]([H])(CC(O)=O)C(N[C@H](C)C(N[C@H]4CC(O) |
溶解度
| In vitro | DMSO | 87 mg/mL (53.68 mM) |
| Water | Warmed: 87 mg/mL (53.68 mM) |
| Ethanol | Insoluble |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 6.17 mL | 30.85 mL | 61.7 mL |
| 0.5 mM | 1.23 mL | 6.17 mL | 12.34 mL |
| 1 mM | 0.62 mL | 3.09 mL | 6.17 mL |
| 5 mM | 0.12 mL | 0.62 mL | 1.23 mL |
*The above data is based on the productmolecular weight 1620.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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