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Daphnetin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Daphnetin图片
CAS NO:486-35-1
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
7,8-Dihydroxycoumarin
产品介绍

生物活性

Daphnetin是一种香豆素类似物,可作为几种蛋白激酶的抑制剂。它在体外抑制EGFR激酶(IC50 = 7.67 ?M),PKA(IC50 = 9.33 ?M)和PKC(IC50 = 25 ?M)。蜂胶对EGFR激酶的抑制作用与ATP竞争,对肽底物没有竞争性。还可以用作有效的抗氧化剂和抗疟疾剂。

靶点信息

EGFRPKAPKC
7.67 μM9.33 μM25.01 μM

化学数据

目录号A10286
作用机制Inhibitor (抑制剂)
M. Wt178.1
FormulaC9H6O4
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.486-35-1
Synonyms7,8-dihydroxycoumarin
SMILESC1=CC(=C(C2=C1C=CC(=O)O2)O)O

溶解度

In vitroDMSO33 mg/mL (185.24 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM56.15 mL280.74 mL561.48 mL
0.5 mM11.23 mL56.15 mL112.3 mL
1 mM5.61 mL28.07 mL56.15 mL
5 mM1.12 mL5.61 mL11.23 mL

*The above data is based on the productmolecular weight 178.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.