生物活性
Cytarabine通过掺入DNA抑制DNA复制（L1210和CEM细胞系中IC50 = 0.04μM）。
靶点信息
| DNA synthesis (CCRF-CEM cells) (CCRF-CEM cells) | | | | |
| 16 nM | | | | |
化学数据
| 目录号 | A10265 |
| M. Wt | 243.2 |
| Formula | C9H13N3O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 147-94-4 |
| Synonyms | Cytosine b-D-arabinofuranoside, cytosine arabinoside, Ara-C |
| SMILES | C1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)O |
溶解度
| In vitro (25°C) | DMSO | 1 mg/mL (4.11 mM) |
| Water | 41 mg/mL (168.57 mM) |
| Ethanol | Insoluble |
| In vivo | Saline | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 41.12 mL | 205.59 mL | 411.18 mL |
| 0.5 mM | 8.22 mL | 41.12 mL | 82.24 mL |
| 1 mM | 4.11 mL | 20.56 mL | 41.12 mL |
| 5 mM | 0.82 mL | 4.11 mL | 8.22 mL |
*The above data is based on the productmolecular weight 243.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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