生物活性
CYT997 (Lexibulin)是一种新型的抗癌血管分裂剂(VDA)。在体外，CYT997被证明可有效抑制血管内皮生长因子刺激的人脐静脉内皮细胞（IC（50）3.7±1.8 nM）的增殖，并在100 nM时引起明显的形态变化，包括膜起泡。
靶点信息
| Microtubules (cancer cell lines) | | | | |
| 10 nM-100 nM | | | | |
化学数据
| 目录号 | A10264 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 434.5 |
| Formula | C24H30N6O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 917111-44-5 |
| Synonyms | CYT-997, Lexibulin |
| SMILES | CCC[C@@H](C1=CN=CC=C1)NC2=NC(=NC=C2C)C3=CC(=C(C=C3)NC(=O)NCC)OC |
溶解度
| In vitro | DMSO | 77 mg/mL (177.2 mM) |
| Water | Insoluble |
| Ethanol | 18 mg/mL (41.42 mM) |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 23.01 mL | 115.07 mL | 230.15 mL |
| 0.5 mM | 4.6 mL | 23.01 mL | 46.03 mL |
| 1 mM | 2.3 mL | 11.51 mL | 23.01 mL |
| 5 mM | 0.46 mL | 2.3 mL | 4.6 mL |
*The above data is based on the productmolecular weight 434.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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