生物活性
Cisplatin是一种无机铂络合物，在肿瘤细胞中能够通过形成DNA加合物抑制 DNA synthesis。建议使用DMF溶解，而不是DMSO。
靶点信息
| DNA synthesis (Tumor cells) | | | | |
| | | | |
化学数据
| 目录号 | A10221 |
| M. Wt | 300.1 |
| Formula | Cl2H4N2Pt |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 15663-27-1 |
| Synonyms | cisplatinum, CDDP, cis-diamminedichloroplatinum(II) |
| SMILES | N.N.Cl[Pt+2]Cl |
溶解度
| In vitro | DMSO | 56 mg/mL (186.63 mM) |
| Water | DMF: 11 mg/mL (36.66 mM) |
| Ethanol | Insoluble |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 33.32 mL | 166.61 mL | 333.22 mL |
| 0.5 mM | 6.66 mL | 33.32 mL | 66.64 mL |
| 1 mM | 3.33 mL | 16.66 mL | 33.32 mL |
| 5 mM | 0.67 mL | 3.33 mL | 6.66 mL |
*The above data is based on the productmolecular weight 300.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
m.cnreagent.com