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LY3039478
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LY3039478图片
CAS NO:1421438-81-4
规格:98%
分子量:464.44
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Notch inhibitor, novel and potent
CAS:1421438-81-4
分子式:C22H23F3N4O4
分子量:464.44
纯度:98%
存储:Store at -20°C

Background:

LY3039478 is a novel and potent Notch inhibitor with IC50 of 0.41 nM.


The novel and unique Notch Inhibitor, LY3039478, has progressed into clinical development by Lilly co. ltd. LY3039478 displays the best overall profile and is unique within the SAR investigated. LY3039478 Displays Interesting Atropisomer Phenomena. The average LY3039478 major/minor rotational isomer ratio ranged between 14 and 28 in plasma. The crystalline monohydrate form of LY3039478 consists of a single rotational isomer and is chemically and physically stable for at least 14 days under accelerated stability test conditions.


Reference:
[1].Warren J.? Porter. Discovery of a Novel Notch Inhibitor. The 8th SCI-RSC Symposium on Proteinase Inhibitor Design April 15-16, 2013, Basel, Switzerland.