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RU-SKI 43
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RU-SKI 43图片
CAS NO:1043797-53-0
规格:98%
分子量:386.55
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
50mg电议

产品介绍
RU-SKI 43是Hedgehog乙酰转移酶Hhat抑制剂。
CAS:1043797-53-0
分子式:C22H30N2O2S
分子量:386.55
纯度:98%
存储:Store at -20°C

Background:

RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.IC50 value:Target: Hhat inhibitorRU-SKI 43 reduced pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling. In addition, RU-SKI 43 treatment inhibited two key proliferative pathways regulated by Akt and mTOR.




[1]. Petrova E, et al. Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene. 2014 Jan 27. doi: 10.1038/onc.2013.575.