5-HT uptake facilitator,selective,antidepressant
CAS：30123-17-2
分子式：C21H24ClN2NaO4S
分子量：458.93
纯度：98%
存储：Store at -20°C

Background:

Tianeptine sodium salt is a selective facilitator of 5-HT uptake in vitro and in vivo. IC50 Value:Target: 5-HT ReceptorTianeptine has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50 >10 μM) and has no effect on noradrenalin or dopamine uptake. Antidepressant, analgesic and neuroprotective following systemic administration in vivo.

参考文献:
[1]. Broqua P; Baudrie V; Chaouloff F Differential effects of the novel antidepressant tianeptine on L-5-hydroxytryptophan (5-HTP)-elicited corticosterone release and body weight loss. Eur Neuropsychopharmacol. 1992 Jun;2(2):115-20.
[2]. Orescanin-Dusic Z, et al. Tianeptine's effects on spontaneous and Ca2+-induced uterine smooth muscle contraction. Acta Physiol Hung. 2012 Jun;99(2):140-7.
[3]. Della FP, Abelaira HM, Réus GZ, Ribeiro KF, Antunes AR, Scaini G, Jeremias IC, Dos Santos LM, Jeremias GC, Streck EL, Quevedo J.Tianeptine treatment induces antidepressive-like effects and alters BDNF and energy metabolism in the brain of rats.Behav Brain Res. 2012 Aug 1;233(2):526-35. Epub 2012 May 31.
[4]. Sohn W, Lee OY, Kwon JG, Park KS, Lim YJ, Kim TH, Jung SW, Kim JI.Tianeptine vs amitriptyline for the treatment of irritable bowel syndrome with diarrhea: a multicenter, open-label, non-inferiority, randomized controlled study.Neurogastroenterol Motil. 2012 Sep;24(9):860-e398.
[5]. Orola L, Veidis MV, Sarcevica I, Actins A, Belyakov S, Platonenko A.The effect of pH on polymorph formation of the pharmaceutically active compound tianeptine.Int J Pharm. 2012 Aug 1;432(1-2):50-6. Epub 2012 Apr 30.