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CHIR-99021
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CHIR-99021图片
CAS NO:252917-06-9
包装与价格:
包装价格(元)
2mg电议
5mg电议
25mg电议
100mg电议

产品名称
GSK-3 Inhibitor XVI, CT 99021, CHIR99021
产品介绍

生物活性

CHIR99021是一种GSK-3α和GSK-3β抑制剂,IC50值分别为10和6.7 nM。

靶点信息

GSK-3βGSK-3α
6.7 nM10 nM

化学数据

目录号A10199
作用机制Inhibitor (抑制剂)
M. Wt465.3
FormulaC22H18Cl2N8
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.252917-06-9
SynonymsGSK-3 Inhibitor XVI, CT 99021, CHIR99021
SMILESCC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N

溶解度

In vitro (25°C)DMSOWarmed: 9 mg/mL (19.33 mM)
WaterInsoluble
EthanolInsoluble
In vivo4% DMSO+30% PEG 300+ddH2O3.3 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM21.49 mL107.46 mL214.92 mL
0.5 mM4.3 mL21.49 mL42.98 mL
1 mM2.15 mL10.75 mL21.49 mL
5 mM0.43 mL2.15 mL4.3 mL

*The above data is based on the productmolecular weight 465.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.