您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Dovitinib Dilactic acid(TKI258 Dilactic acid)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Dovitinib Dilactic acid(TKI258 Dilactic acid)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dovitinib Dilactic acid(TKI258 Dilactic acid)图片
CAS NO:852433-84-2
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
CHIR-258, TKI258
产品介绍

生物活性

Dovitinib是一种小分子多靶点酪氨酸激酶抑制剂,可抑制通过ZNF198-FGFR1或BCR-FGFR1转化为IL3独立性的Ba / F3细胞,IC50值分别为150 nM和90 nM。

Targets

TargetValue
FLT3IC50: 1nM
c-KitIC50: 2nM
FGFR1IC50: 8nM
VEGFR3/FLT4IC50: 8nM
FGFR3IC50: 9nM
VEGFR1/FLT1IC50: 10nM
VEGFR2/Flk1IC50: 13nM
PDGFRβIC50: 27nM
CSF-1R/c-FmsIC50: 36nM
PDGFRαIC50: 210nM
Insulin ReceptorIC50: 2μM
EGFRIC50: 2μM
c-MetIC50: >3μM
EphA2IC50: 4μM
Tie-2IC50: 4μM
IGF-1RIC50: >10μM
HER2IC50: >10μM

化学数据

目录号A10198
作用机制Inhibitor (抑制剂)
M. Wt572.6
FormulaC21H21FN6O.2C3H6O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.852433-84-2
SynonymsCHIR-258, TKI258
SMILESCC(C(=O)O)O.CC(C(=O)O)O.CN1CCN(CC1)C2=CC3=C(C=C2)N/C(=C/4\C(=C5C(=NC4=O)C=CC=C5F)N)/N3

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM17.46 mL87.32 mL174.64 mL
0.5 mM3.49 mL17.46 mL34.93 mL
1 mM1.75 mL8.73 mL17.46 mL
5 mM0.35 mL1.75 mL3.49 mL

*The above data is based on the productmolecular weight 572.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.