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Cerubidine(Daunorubicin HCl,Rubidomycin HCl)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cerubidine(Daunorubicin HCl,Rubidomycin HCl)图片
CAS NO:23541-50-6
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
Daunorubicin HCl, Rubidomycin HCl
产品介绍

生物活性

Cerubidine (Daunorubicin HCl,Rubidomycin HCl)通过插入和抑制大分子生物合成与DNA相互作用。这抑制了拓扑异构酶II的进程,该酶使DNA中的超螺旋松弛以进行转录。

靶点信息

DNA synthesis (Cell-free assay)
20 nM(Ki)

化学数据

目录号A10194
作用机制Inhibitor (抑制剂)
M. Wt564.0
FormulaC27H29NO10.HCl
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.23541-50-6
SynonymsDaunorubicin HCl, Rubidomycin HCl
SMILESC[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)C)O)N)O.Cl

溶解度

In vitro (25°C)DMSO93 mg/mL (164.9 mM)
Water93 mg/mL (164.9 mM)
EthanolInsoluble
In vivoSaline28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM17.73 mL88.65 mL177.3 mL
0.5 mM3.55 mL17.73 mL35.46 mL
1 mM1.77 mL8.87 mL17.73 mL
5 mM0.35 mL1.77 mL3.55 mL

*The above data is based on the productmolecular weight 564.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.