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Cediranib(AZD2171)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cediranib(AZD2171)图片
CAS NO:288383-20-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
Recentin
产品介绍

生物活性

Cediranib (AZD2171)是一种高效的VEGFR(KDR)抑制剂,此外对c-Kit和PDGFRβ也具有相似的抑制活性,对VEGFR的选择性比PDGFR-α,CSF-1R和Flt3分别高36倍,110倍 和1000倍以上。

Targets

TargetValue
VEGFR2/KDRIC50: 0.5nM
c-KitIC50: 2nM
VEGFR3/FLT4IC50:<=3nM
VEGFR1/FLT1IC50: 5nM
PDGFRβIC50: 5nM
FGFR1IC50: 26nM
PDGFRαIC50: 36nM
CSF-1RIC50: 110nM
SrcIC50: 130nM
AblIC50: 260nM
FLT3IC50: >1μM
HER2/ErbB2IC50: >1μM
CDK2IC50: >1μM
CDK4IC50: >1μM
EGFRIC50: 1.6μM
AuroraAIC50: >10μM
AuroraBIC50: >10μM
MEKIC50: >10μM

化学数据

目录号A10185
作用机制Inhibitor (抑制剂)
M. Wt450.5
FormulaC25H27FN4O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.288383-20-0
SynonymsRecentin
SMILESCC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCC5

溶解度

In vitro (25°C)DMSO80 mg/mL (177.57 mM)
WaterInsoluble
EthanolInsoluble
In vivo5% DMSO+50% PEG 300+5% Tween+ddH2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM22.2 mL110.99 mL221.98 mL
0.5 mM4.44 mL22.2 mL44.4 mL
1 mM2.22 mL11.1 mL22.2 mL
5 mM0.44 mL2.22 mL4.44 mL

*The above data is based on the productmolecular weight 450.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.