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Asp-AMS
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Asp-AMS图片
CAS NO:828288-98-8
规格:98%
分子量:461.41
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Asp-AMS是天冬氨酸腺苷酸的一个类似物,是aspartyl-tRNA合成酶(aspartyl-tRNAsynthetase)的一个抑制剂,也是线粒体酶(mitochondrialenzyme)的强效竞争性抑制剂。
CAS:828288-98-8
分子式:C14H19N7O9S
分子量:461.41
纯度:98%
存储:Store at -20°C

Background:

Asp-AMS, an analogue of aspartyl-adenylate, is an aspartyl-tRNA synthetase inhibitor and also a strong competitive inhibitor of the mitochondrial enzyme.


Asp-AMS is a 500-fold stronger competitive inhibitor of the mitochondrial enzyme than aspartol-AMP (10 nM) and a 35-fold lower competitor of human and bovine cyt-AspRSs (300 nM). Asp-AMS is a strong inhibitor with Ki in the nanomolar (nM) range. Asp-AMS has also the highest inhibitory effect for the mitochondrial enzyme. Asp-AMS is the most active inhibitor with Ki values in the nanomolar range, with a stronger effect on bacterial AspRSs (E. coli and P. aeruginosa) than on human cytosolic AspRS[1].



[1]. Messmer M, et al. Peculiar inhibition of human mitochondrial aspartyl-tRNA synthetase by adenylate analogs. Biochimie. 2009 May;91(5):596-603.