Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) 是一种创伤弧菌的群体感应分子，通过与 RIG-I 的特异性相互作用，抑制 RIG-I 的多泛素化，并抑制 IRF-3 的激活和 I 型干扰素的产生。Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) 增强 HCV 和流感病毒的易感性。
CAS：14705-60-3
分子式：C14H16N2O2
分子量：244.29
纯度：98%
存储：Store at -20°C

Background:

Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)), a Vibrio vulnificus quorum-sensing molecule, inhibits retinoic acid-inducible gene-I (RIG-I) polyubiquitination, through its specific interaction with RIG-I, to blunt IRF-3 activation and type-I IFN production. Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) enhances susceptibility to hepatitis C virus (HCV), as well as Sendai and influenza viruses[1].

[1]. Lee W, et al. Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity. Nat Commun. 2018 Apr 23;9(1):1606.