PROTAC Linker 8 (Compound 15b) 是一种 PROTAC 连接桥，可用于合成一系列 SNIPER(ER)。SNIPER(ER) 含有两个通过连接桥连接的不同配体，一种是 E3 泛素连接酶配体，另一种是靶蛋白配体。 SNIPER(ER) 诱导细胞中靶蛋白多泛素化和蛋白酶体降解。
CAS：51951-05-4
分子式：C8H16O6
分子量：208.21
纯度：98%
存储：Store at -20°C

Background:

PROTAC Linker 8 (Compound 15b) is a PROTAC linker can be used in the synthesis of a series of SNIPER(ER)s. SNIPER(ER)s contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. SNIPER(ER)s induce polyubiquitylation and proteasomal degradation of the target proteins in the cells[1]. Alkyl/ether

[1]. Ohoka N, et al. In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs). J Biol Chem. 2017 Mar 17;292(11):4556-4570.