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BIX 02189
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BIX 02189图片
CAS NO:1094614-85-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
BIX02189, BIX-02189
产品介绍

生物活性

BIX 02189是选择性双重MEK5和ERK5(或BMK1)激酶抑制剂,对于MEK5,ERK5,TGFbR1和其他紧密相关的激酶,IC50值分别为1.5、59、580和> 6200 nM。

Targets

TargetValue
MEK5IC50: 1.5nM
ERK5IC50: 59nM
TGFβR1IC50: 580nM
MEK1IC50: >6.2μM
MEK2IC50: >6.2μM
ERK1IC50: >6.2μM
JNK2IC50: >6.2μM
EGFRIC50: >6.3μM
STK16IC50: >6.3μM

化学数据

目录号A10151
作用机制Inhibitor (抑制剂)
M. Wt440.5
FormulaC27H28N4O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1094614-85-3
SynonymsBIX02189, BIX-02189
SMILESCN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N(C)C)NC2=O)/C4=CC=CC=C4

溶解度

In vitro (25°C)DMSOWarmed: 56 mg/mL (127.11 mM)
WaterInsoluble
Ethanol75 mg/mL (170.24 mM)
In vivo2% DMSO+30% PEG 300+5% Tween 80+ddH2O9 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM22.7 mL113.51 mL227.01 mL
0.5 mM4.54 mL22.7 mL45.4 mL
1 mM2.27 mL11.35 mL22.7 mL
5 mM0.45 mL2.27 mL4.54 mL

*The above data is based on the productmolecular weight 440.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.