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Doramapimod(BIRB-796)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Doramapimod(BIRB-796)图片
CAS NO:285983-48-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
BIRB-796,BIRB 796
产品介绍

生物活性

Doramapimod(BIRB 796)是p38 MAPK的小分子抑制剂,在调节促炎细胞因子的产生中起关键作用。

靶点信息

p38α (Cell-free assay)p38α
0.1 nM(Kd)38 nM

化学数据

目录号A10148
作用机制Inhibitor (抑制剂)
M. Wt527.7
FormulaC31H37N5O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.285983-48-4
SynonymsBIRB-796,BIRB 796
SMILESCC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5

溶解度

In vitro (25°C)DMSO99 mg/mL (187.61 mM)
WaterInsoluble
Ethanol99 mg/mL (187.61 mM)
In vivo5% DMSO+40%PEG300+5%Tween80??+50%H2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM18.95 mL94.75 mL189.5 mL
0.5 mM3.79 mL18.95 mL37.9 mL
1 mM1.9 mL9.48 mL18.95 mL
5 mM0.38 mL1.9 mL3.79 mL

*The above data is based on the productmolecular weight 527.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.