生物活性
Doramapimod(BIRB 796)是p38 MAPK的小分子抑制剂,在调节促炎细胞因子的产生中起关键作用。
靶点信息
p38α (Cell-free assay) | p38α | | | |
0.1 nM(Kd) | 38 nM | | | |
化学数据
目录号 | A10148 |
作用机制 | Inhibitor (抑制剂) |
M. Wt | 527.7 |
Formula | C31H37N5O3 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 285983-48-4 |
Synonyms | BIRB-796,BIRB 796 |
SMILES | CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5 |
溶解度
In vitro (25°C) | DMSO | 99 mg/mL (187.61 mM) |
Water | Insoluble |
Ethanol | 99 mg/mL (187.61 mM) |
In vivo | 5% DMSO+40%PEG300+5%Tween80??+50%H2O | 4 mg/mL |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 18.95 mL | 94.75 mL | 189.5 mL |
0.5 mM | 3.79 mL | 18.95 mL | 37.9 mL |
1 mM | 1.9 mL | 9.48 mL | 18.95 mL |
5 mM | 0.38 mL | 1.9 mL | 3.79 mL |
*The above data is based on the productmolecular weight 527.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.