生物活性
Bafetinib (INNO-406)是一种双重Bcr-Abl/Lyn酪氨酸激酶抑制剂。
靶点信息
| Abl (Cell-free assay) | Lyn (Cell-free assay) | | | |
| 5.8 nM | 19 nM | | | |
化学数据
| 目录号 | A10119 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 576.6 |
| Formula | C30H31F3N8O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 859212-16-1 |
| Synonyms | NS-187 |
| SMILES | CC1=C(C=C(C=C1)NC(=O)C2=CC(=C(C=C2)CN3CC[C@@H](C3)N(C)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CN=C5 |
溶解度
| In vitro (25°C) | DMSO | 92 mg/mL (159.55 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 0.5% methylcellulose+0.2% Tween 80 | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 17.34 mL | 86.72 mL | 173.43 mL |
| 0.5 mM | 3.47 mL | 17.34 mL | 34.69 mL |
| 1 mM | 1.73 mL | 8.67 mL | 17.34 mL |
| 5 mM | 0.35 mL | 1.73 mL | 3.47 mL |
*The above data is based on the productmolecular weight 576.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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