生物活性
AZD8931 (Sapitinib)是ErbB1，ErbB2和ErbB3受体信号传导的等效抑制剂。
靶点信息
| ErbB2 (Cell-free assay) | EGFR (Cell-free assay) | ErbB3 (Cell-free assay) | | |
| 3 nM | 4 nM | 4 nM | | |
化学数据
| 目录号 | A10116 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 473.9 |
| Formula | C23H25ClFN5O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 848942-61-0 |
| Synonyms | AZD-8931, Momelotinib, Sapitinib |
| SMILES | CNC(=O)CN1CCC(CC1)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC |
溶解度
| In vitro (25°C) | DMSO | 37 mg/mL (78.07 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 4 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 21.1 mL | 105.51 mL | 211.01 mL |
| 0.5 mM | 4.22 mL | 21.1 mL | 42.2 mL |
| 1 mM | 2.11 mL | 10.55 mL | 21.1 mL |
| 5 mM | 0.42 mL | 2.11 mL | 4.22 mL |
*The above data is based on the productmolecular weight 473.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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