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AZD8055
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AZD8055图片
CAS NO:1009298-09-2
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
AZD-8055
产品介绍

生物活性

AZD8055是一种有效的,选择性的ATP竞争性mTOR激酶抑制剂,IC50为0.8 nM。

Targets

TargetValue
mTOR(truncated)IC50: 0.13nM
mTOR(fulllength)IC50: 0.8nM
DNA-PKIC50: 1370nM
PI3KδIC50: 3200nM
PI3KαIC50: 3590nM
ATMIC50: 7350nM
PI3KγIC50: >14790nM
PI3KβIC50: 18900nM

化学数据

目录号A10114
作用机制Inhibitor (抑制剂)
M. Wt465.5
FormulaC25H31N5O4
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1009298-09-2
SynonymsAZD-8055
SMILESC[C@H]1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=C(C=C4)OC)CO)N5CCOC[C@@H]5C

溶解度

In vitro (25°C)DMSOWarmed: 49 mg/mL (105.25 mM)
WaterInsoluble
Ethanol3 mg/mL (6.44 mM)
In vivo4% DMSO+30% PEG 300+ddH2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM21.48 mL107.41 mL214.82 mL
0.5 mM4.3 mL21.48 mL42.96 mL
1 mM2.15 mL10.74 mL21.48 mL
5 mM0.43 mL2.15 mL4.3 mL

*The above data is based on the productmolecular weight 465.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.