生物活性
Olaparib (AZD2281)是聚ADP核糖聚合酶（PARP）的抑制剂，该酶是一种与DNA修复有关的酶。
靶点信息
| PARP2 (Cell-free assay) | PARP1 (Cell-free assay) | Tankyrase-1 (Cell-free assay) | | |
| 1 nM | 5 nM | 1.5 μM | | |
化学数据
| 目录号 | A10111 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 434.5 |
| Formula | C24H23FN4O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 763113-22-0 |
| Synonyms | KU-0059436 |
| SMILES | C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F |
溶解度
| In vitro (25°C) | DMSO | Warmed: 74 mg/mL (170.32 mM) |
| Water | <1 mg/mL |
| Ethanol | Insoluble |
| In vivo | 4% DMSO+30% PEG 300+ddH2O | 4 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 23.01 mL | 115.07 mL | 230.15 mL |
| 0.5 mM | 4.6 mL | 23.01 mL | 46.03 mL |
| 1 mM | 2.3 mL | 11.51 mL | 23.01 mL |
| 5 mM | 0.46 mL | 2.3 mL | 4.6 mL |
*The above data is based on the productmolecular weight 434.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
m.cnreagent.com