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AZD1152-HQPA(Barasertib)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AZD1152-HQPA(Barasertib)图片
CAS NO:722544-51-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
Barasertib
产品介绍

生物活性

AZD1152-HQPA (Barasertib)是Aurora B的高效抑制剂,Ki值分别为0.36(Aurora B)和1369 nM(Aurora A),与一组其他50种激酶相比具有很高的特异性。

靶点信息

Aurora B (Cell-free assay)Aurora A (Cell-free assay)
0.37 nM1368 nM

化学数据

目录号A10109
作用机制Inhibitor (抑制剂)
M. Wt507.7
FormulaC26H30FN7O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.722544-51-6
SynonymsBarasertib
SMILESCCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCO

溶解度

In vitro (25°C)DMSO93 mg/mL (183.23 mM)
WaterInsoluble
Ethanol3 mg/mL (5.91 mM)
In vivo2% DMSO+40% PEG 300+2% Tween 80+ddH2O6 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM19.7 mL98.48 mL196.97 mL
0.5 mM3.94 mL19.7 mL39.39 mL
1 mM1.97 mL9.85 mL19.7 mL
5 mM0.39 mL1.97 mL3.94 mL

*The above data is based on the productmolecular weight 507.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.