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Saracatinib(AZD0530)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Saracatinib(AZD0530)图片
CAS NO:379231-04-6
包装与价格:
包装价格(元)
10mg电议
25mg电议
100mg电议
200mg电议
10mM * 1mL in DMSO电议

产品名称
AZD-0530
产品介绍

生物活性

Saracatinib (AZD0530)是一种高选择性,双特异性Src/Abl激酶抑制剂,对c-Src和Abl激酶的IC50分别为2.7和30 nM。

Targets

TargetValue
c-SrcIC50: 2.7nM
LCKIC50:<4nM
c-YESIC50: 4nM
EGFR(L861Q)IC50: 4nM
LynIC50: 5nM
EGFR(L858R)IC50: 5nM
FynIC50: 10nM
FGRIC50: 10nM
BLKIC50: 11nM
v-AblIC50: 30nM
EGFRIC50: 66nM
c-KitIC50: 200nM
EphA2IC50: 236nM
CSKIC50: >1μM
PDGFRβIC50: >5μM
PDGFRαIC50: 10μM
CDK2IC50: 10μM
VEGFR3/FLT4IC50: >10μM
FGFR1IC50: >10μM
MEKIC50: 14μM
VEGFR2/KDRIC50: 21μM
VEGFR1/FLT1IC50: >100μM

化学数据

目录号A10108
作用机制Inhibitor (抑制剂)
M. Wt542.0
FormulaC27H32ClN5O5
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.379231-04-6
SynonymsAZD-0530
SMILESCN1CCN(CC1)CCOC2=CC(=C3C(=C2)N=CN=C3NC4=C(C=CC5=C4OCO5)Cl)OC6CCOCC6

溶解度

In vitro (25°C)DMSOWarmed: 34 mg/mL (62.73 mM)
WaterInsoluble
Ethanol30 mg/mL (55.35 mM)
In vivo2% DMSO+30% PEG 300+ddH2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM18.45 mL92.25 mL184.5 mL
0.5 mM3.69 mL18.45 mL36.9 mL
1 mM1.85 mL9.23 mL18.45 mL
5 mM0.37 mL1.85 mL3.69 mL

*The above data is based on the productmolecular weight 542.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.