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AZ-960
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AZ-960图片
CAS NO:905586-69-8
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
AZ960
产品介绍

生物活性

AZ-960是一种有效的,选择性的和ATP竞争性的JAK2抑制剂,在体外抑制JAK2激酶的Ki为0.45 nM,并诱导成年T细胞白血病(ATL)细胞的生长停滞和凋亡

靶点信息

JAK2JAK2
0.45 nM(Ki)<3 nM

化学数据

目录号A10104
作用机制Inhibitor (抑制剂)
M. Wt354.4
FormulaC18H16F2N6
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.905586-69-8
SynonymsAZ960
SMILESCC1=CC(=NN1)NC2=C(C=C(C(=N2)N[C@@H](C)C3=CC=C(C=C3)F)C#N)F

溶解度

In vitroDMSO70 mg/mL (197.54 mM)
WaterInsoluble
Ethanol3 mg/mL (8.46 mM)
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM28.22 mL141.08 mL282.17 mL
0.5 mM5.64 mL28.22 mL56.43 mL
1 mM2.82 mL14.11 mL28.22 mL
5 mM0.56 mL2.82 mL5.64 mL

*The above data is based on the productmolecular weight 354.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.