生物活性
AZ-960是一种有效的,选择性的和ATP竞争性的JAK2抑制剂,在体外抑制JAK2激酶的Ki为0.45 nM,并诱导成年T细胞白血病(ATL)细胞的生长停滞和凋亡
靶点信息
化学数据
目录号 | A10104 |
作用机制 | Inhibitor (抑制剂) |
M. Wt | 354.4 |
Formula | C18H16F2N6 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 905586-69-8 |
Synonyms | AZ960 |
SMILES | CC1=CC(=NN1)NC2=C(C=C(C(=N2)N[C@@H](C)C3=CC=C(C=C3)F)C#N)F |
溶解度
In vitro | DMSO | 70 mg/mL (197.54 mM) |
Water | Insoluble |
Ethanol | 3 mg/mL (8.46 mM) |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 28.22 mL | 141.08 mL | 282.17 mL |
0.5 mM | 5.64 mL | 28.22 mL | 56.43 mL |
1 mM | 2.82 mL | 14.11 mL | 28.22 mL |
5 mM | 0.56 mL | 2.82 mL | 5.64 mL |
*The above data is based on the productmolecular weight 354.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.