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Axitinib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Axitinib图片
CAS NO:319460-85-0
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
10mM * 1mL in DMSO电议

产品名称
AG 013736
产品介绍

生物活性

Axitinib是一种小分子酪氨酸激酶抑制剂,可抑制多种靶标,包括VEGFR-1,VEGFR-2,VEGFR-3,血小板衍生生长因子受体(PDGFR)和cKIT(CD117)。

Targets

TargetValue
VEGFR1/FLT1IC50: 0.1nM
VEGFR2/Flk1IC50: 0.18nM
VEGFR2/KDRIC50: 0.2nM
VEGFR3IC50: 0.1nM-0.3nM
PDGFRβIC50: 1.6nM
KitIC50: 1.7nM
PDGFRαIC50: 5.0nM
CSF-1RIC50: 73nM
FLT3IC50: >1μM

化学数据

目录号A10103
作用机制Inhibitor (抑制剂)
M. Wt386.5
FormulaC22H18N4OS
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.319460-85-0
SynonymsAG 013736
SMILESCNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=CC=N4

溶解度

In vitroDMSOWarmed: 30 mg/mL (77.62 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM25.87 mL129.37 mL258.73 mL
0.5 mM5.17 mL25.87 mL51.75 mL
1 mM2.59 mL12.94 mL25.87 mL
5 mM0.52 mL2.59 mL5.17 mL

*The above data is based on the productmolecular weight 386.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.