生物活性
Avasimibe (CI-1011)是口服可生物利用的酰基辅酶A：胆固醇O-酰基转移酶（ACAT）抑制剂，IC50分别为2.9 μM， 13.9 μM和26.5 μM。
靶点信息
| CYP2C9 | ACAT | CYP1A2 | CYP2C19 | |
| 2.9 μM | 3.3 μM | 13.9 μM | 26.5 μM | |
化学数据
| 目录号 | A10102 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 501.7 |
| Formula | C29H43NO4S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 166518-60-1 |
| Synonyms | CI-1011, CI1011, PD 148515 |
| SMILES | CC(C)C1=C(C(=CC=C1)C(C)C)OS(=O)(=O)NC(=O)CC2=C(C=C(C=C2C(C)C)C(C)C)C(C)C |
溶解度
| In vitro (25°C) | DMSO | 96 mg/mL (191.34 mM) |
| Water | Insoluble |
| Ethanol | 8 mg/mL (15.94 mM) |
| In vivo | 2% DMSO+corn oil | 4 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 19.93 mL | 99.66 mL | 199.32 mL |
| 0.5 mM | 3.99 mL | 19.93 mL | 39.86 mL |
| 1 mM | 1.99 mL | 9.97 mL | 19.93 mL |
| 5 mM | 0.4 mL | 1.99 mL | 3.99 mL |
*The above data is based on the productmolecular weight 501.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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