您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Avasimibe(CI-1011)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Avasimibe(CI-1011)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Avasimibe(CI-1011)图片
CAS NO:166518-60-1
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议
200mg电议
10mM * 1mL in DMSO电议

产品名称
CI-1011, CI1011, PD 148515
产品介绍

生物活性

Avasimibe (CI-1011)是口服可生物利用的酰基辅酶A:胆固醇O-酰基转移酶(ACAT)抑制剂,IC50分别为2.9 μM, 13.9 μM和26.5 μM。

靶点信息

CYP2C9ACATCYP1A2CYP2C19
2.9 μM3.3 μM13.9 μM26.5 μM

化学数据

目录号A10102
作用机制Inhibitor (抑制剂)
M. Wt501.7
FormulaC29H43NO4S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.166518-60-1
SynonymsCI-1011, CI1011, PD 148515
SMILESCC(C)C1=C(C(=CC=C1)C(C)C)OS(=O)(=O)NC(=O)CC2=C(C=C(C=C2C(C)C)C(C)C)C(C)C

溶解度

In vitro (25°C)DMSO96 mg/mL (191.34 mM)
WaterInsoluble
Ethanol8 mg/mL (15.94 mM)
In vivo2% DMSO+corn oil4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM19.93 mL99.66 mL199.32 mL
0.5 mM3.99 mL19.93 mL39.86 mL
1 mM1.99 mL9.97 mL19.93 mL
5 mM0.4 mL1.99 mL3.99 mL

*The above data is based on the productmolecular weight 501.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.