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Artesunate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Artesunate图片
CAS NO:88495-63-0
包装与价格:
包装价格(元)
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品介绍

生物活性

Artesunate是用于治疗疟疾的青蒿素的半合成衍生物。它也被证明可以有效对抗其他寄生虫,例如肝吸虫。青蒿琥酯还显示出针对不同肿瘤类型的癌细胞系的细胞毒性作用。青蒿琥酯已显示出通过抑制类风湿关节炎成纤维细胞样滑膜细胞中的NF-B和PI3激酶/ Akt信号通路来抑制TNF诱导的促炎细胞因子的产生。

靶点信息

EXP1(a membrane glutathione S-transferase)

化学数据

目录号A10087
作用机制Inhibitor (抑制剂)
M. Wt384.4
FormulaC19H28O8
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.88495-63-0
SMILESC[C@@H]1CC[C@H]2[C@H]([C@@H](O[C@H]3[C@@]24[C@H]1CCC(O3)(OO4)C)OC(=O)CCC(=O)O)C

溶解度

In vitroDMSO69 mg/mL (179.49 mM)
WaterInsoluble
Ethanol69 mg/mL (179.49 mM)
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM26.01 mL130.07 mL260.15 mL
0.5 mM5.2 mL26.01 mL52.03 mL
1 mM2.6 mL13.01 mL26.01 mL
5 mM0.52 mL2.6 mL5.2 mL

*The above data is based on the productmolecular weight 384.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.