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Aprepitant(MK-0869)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Aprepitant(MK-0869)图片
CAS NO:170729-80-3
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
25mg电议
10mM * 1mL in DMSO电议

产品名称
MK0869, MK-869, L-754030, Emend
产品介绍

生物活性

Aprepitant (MK-0869)被归类为NK1拮抗剂。已经显示,阿瑞匹坦通过阻止P物质降落在大脑神经元受体上,从而抑制细胞毒性化疗药物引起的急性呕吐和延迟呕吐。还显示出它能增加5-HT3受体拮抗剂恩丹西酮和皮质类固醇地塞米松的活性,它们也可用于预防化学疗法引起的恶心和呕吐。

靶点信息

Neurokinin-1 receptor (Cell-free assay)
0.1 nM

化学数据

目录号A10083
作用机制Antagonist (拮抗剂)
M. Wt534.4
FormulaC23H21F7N4O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.170729-80-3
SynonymsMK0869, MK-869, L-754030, Emend
SMILESC[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NC(=O)NN3)C4=CC=C(C=C4)F

溶解度

In vitro (25°C)DMSO96 mg/mL (179.63 mM)
WaterInsoluble
Ethanol14 mg/mL (26.19 mM)
In vivo5% DMSO+corn oil12 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM18.71 mL93.56 mL187.13 mL
0.5 mM3.74 mL18.71 mL37.43 mL
1 mM1.87 mL9.36 mL18.71 mL
5 mM0.37 mL1.87 mL3.74 mL

*The above data is based on the productmolecular weight 534.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.