生物活性
AP24534 (Ponatinib)是有效的多激酶和pan-BCR-ABL抑制剂。
Targets
Target | Value |
Abl | IC50: 0.37nM |
PDGFRα | IC50: 1.1nM |
VEGFR2 | IC50: 1.5nM |
FGFR1 | IC50: 2.2nM |
c-Src | IC50: 5.4nM |
c-Kit | IC50: 12.5nM |
Insulin Receptor | IC50: >1μM |
IGF-1R | IC50: >1μM |
AuroraA | IC50: >1μM |
CDK2/CyclinE | IC50: >1μM |
化学数据
目录号 | A10080 |
作用机制 | Inhibitor (抑制剂) |
M. Wt | 532.6 |
Formula | C29H27F3N6O |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 943319-70-8 |
Synonyms | Ponatinib |
SMILES | CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5 |
溶解度
In vitro (25°C) | DMSO | 30 mg/mL (56.33 mM) |
Water | Insoluble |
Ethanol | Insoluble |
In vivo | 1% CMC Na | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 18.78 mL | 93.88 mL | 187.76 mL |
0.5 mM | 3.76 mL | 18.78 mL | 37.55 mL |
1 mM | 1.88 mL | 9.39 mL | 18.78 mL |
5 mM | 0.38 mL | 1.88 mL | 3.76 mL |
*The above data is based on the productmolecular weight 532.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.