生物活性
AG 490是EGF受体酪氨酸激酶的选择性抑制剂 (EGFR和ErbB2的IC50值分别为2和13.5μM)。也抑制对Lck,Lyn,Btk,Syk和Src无活性的JAK2。
靶点信息
EGFR (Cell-free assay) | JAK2 (Cell-free assay) | ErbB2 (Cell-free assay) | | |
0.1 μM | ~10 μM | 13.5 μM | | |
化学数据
目录号 | A10047 |
作用机制 | Inhibitor (抑制剂) |
M. Wt | 294.3 |
Formula | C17H14N2O3 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 133550-30-8 |
Synonyms | Tyrphostin AG490 |
SMILES | C1=CC=C(C=C1)CNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N |
溶解度
In vitro (25°C) | DMSO | 54 mg/mL (183.48 mM) |
Water | Insoluble |
Ethanol | 6 mg/mL |
In vivo | 5% DMSO+40% PEG300+5% Tween80+50% ddH2O | 5.93 mg/mL |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 33.98 mL | 169.89 mL | 339.79 mL |
0.5 mM | 6.8 mL | 33.98 mL | 67.96 mL |
1 mM | 3.4 mL | 16.99 mL | 33.98 mL |
5 mM | 0.68 mL | 3.4 mL | 6.8 mL |
*The above data is based on the productmolecular weight 294.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.