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AG14361
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AG14361图片
CAS NO:328543-09-5
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
AG-14361
产品介绍

生物活性

AG14361是一种有效的PARP抑制剂,可在MMR(错配修复)有效/不足的细胞中增强替莫唑胺(TMZ)的细胞毒性。

靶点信息

PARP1 (Cell-free assay)
<5 nM(Ki)

化学数据

目录号A10046
作用机制Inhibitor (抑制剂)
M. Wt320.4
FormulaC19H20N4O
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.328543-09-5
SynonymsAG-14361
SMILESCN(C)CC1=CC=C(C=C1)C2=NC3=CC=CC4=C3N2CCNC4=O

溶解度

In vitro (25°C)DMSO11 mg/mL (34.33 mM)
WaterInsoluble
EthanolInsoluble
In vivo4% DMSO+ddH2O1 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM31.21 mL156.05 mL312.11 mL
0.5 mM6.24 mL31.21 mL62.42 mL
1 mM3.12 mL15.61 mL31.21 mL
5 mM0.62 mL3.12 mL6.24 mL

*The above data is based on the productmolecular weight 320.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.