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AG-014699(Rucaparib)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AG-014699(Rucaparib)图片
CAS NO:459868-92-9
包装与价格:
包装价格(元)
5mg电议
25mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
AG014699, PF-01367338,AG-014447 (as free base)
产品介绍

生物活性

AG-014699 (Rucaparib)是一种PARP抑制剂,可抑制聚(ADP-核糖)聚合酶(PARP,后者是DNA修复中的关键酶。 无细胞试验中作用于PARP1的Ki为1.4 nM,对其余8个PARP位点也有结合亲和力。

靶点信息

PARP (Cell-free assay)
1.4 nM(Ki)

化学数据

目录号A10045
作用机制Inhibitor (抑制剂)
M. Wt421.4
FormulaC19H18FN3O.H3PO4
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.459868-92-9
SynonymsAG014699, PF-01367338,AG-014447 (as free base)
SMILESCNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=CC(=CC(=C34)N2)F.OP(=O)(O)O

溶解度

In vitro (25°C)DMSO81 mg/mL (192.23 mM)
WaterInsoluble
EthanolInsoluble
In vivo2% DMSO+30% PEG 300+2% Tween 80+ddH2O9 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM23.73 mL118.65 mL237.3 mL
0.5 mM4.75 mL23.73 mL47.46 mL
1 mM2.37 mL11.87 mL23.73 mL
5 mM0.47 mL2.37 mL4.75 mL

*The above data is based on the productmolecular weight 421.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.