您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > A-966492
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
A-966492
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
A-966492图片
CAS NO:934162-61-5
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
A966492
产品介绍

生物活性

A-966492在全细胞试验中显示出对K(i)为1 nM,EC(50)为1 nM的聚(ADP-核糖)聚合酶-1(PARP-1)酶的高效力。

靶点信息

PARP1PARP1PARP2
1 nM(Ki)1 nM(EC50)1.5 nM(Ki)

化学数据

目录号A10019
作用机制Inhibitor (抑制剂)
M. Wt324.4
FormulaC18H17FN4O
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.934162-61-5
SynonymsA966492
SMILESC1CC(NC1)C2=CC(=C(C=C2)C3=NC4=C(C=CC=C4N3)C(=O)N)F

溶解度

In vitroDMSOWarmed: 60 mg/mL (184.98 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM30.83 mL154.13 mL308.26 mL
0.5 mM6.17 mL30.83 mL61.65 mL
1 mM3.08 mL15.41 mL30.83 mL
5 mM0.62 mL3.08 mL6.17 mL

*The above data is based on the productmolecular weight 324.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.