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17-AAG(KOS953)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
17-AAG(KOS953)图片
CAS NO:75747-14-7
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议
200mg电议
10mM * 1mL in DMSO电议

产品名称
Tanespimycin, NSC330507, CP 127374, KOS-953, KOS 953
产品介绍

生物活性

17-AAG (KOS953)是一种有效的HSP90抑制剂,无细胞试验中IC50为5 nM,作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。

靶点信息

HSP90 (Cell-free assay)
5 nM

化学数据

目录号A10010
作用机制Inhibitor (抑制剂)
M. Wt585.7
FormulaC31H43N3O8
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.75747-14-7
SynonymsTanespimycin, NSC330507, CP 127374, KOS-953, KOS 953
SMILESCC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC

溶解度

In vitro (25°C)DMSO97 mg/mL (165.61 mM)
WaterInsoluble
Ethanol5 mg/mL
In vivo5%DMSO+corn oil9 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM17.07 mL85.37 mL170.74 mL
0.5 mM3.41 mL17.07 mL34.15 mL
1 mM1.71 mL8.54 mL17.07 mL
5 mM0.34 mL1.71 mL3.41 mL

*The above data is based on the productmolecular weight 585.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.