Procyanidin B3 是一种天然产物，为组蛋白乙酰转移酶 (HAT) 特异性抑制剂，可与 p300 的其他位点而非活性位点结合，选择性地抑制 p300 介导的 androgen 受体乙酰化。Procyanidin B3 对 HDAC 或 组蛋白甲基转移酶 (HMT) 无作用。
CAS：23567-23-9
分子式：C30H26O12
分子量：578.52
纯度：98%
存储：Store at -20°C

Background:

Procyanidin B3 is a natural product, acts as a specific HAT inhibitor, binds to the other site of p300 instead of the active site, selectively inhibits p300-mediated androgen receptor acetylation. Procyanidin B3 has no effect on HDAC or HMT (histone methyltransferase)[1]. p300[1]

[1]. Choi KC, et al. Procyanidin B3, an inhibitor of histone acetyltransferase, enhances the action of antagonist for prostate cancer cells via inhibition of p300-dependent acetylation of androgen receptor. Biochem J. 2011 Jan 1;433(1):235-44.