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PTC-028
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PTC-028图片
CAS NO:1782970-28-8
规格:98%
分子量:405.32
包装与价格:
包装价格(元)
200mg电议
500mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
PTC-028 是一种口服有效的干细胞因子 BMI-1 的抑制剂,可用于治疗卵巢癌。PTC-028 选择性地抑制癌细胞,而正常细胞不受影响。PTC-028 对 BMI-1 的作用可诱导 caspase 介导的细胞凋亡 (apoptosis)。
CAS:1782970-28-8
分子式:C19H12F5N5
分子量:405.32
纯度:98%
存储:Store at -20°C

Background:

PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. PTC-028 selectively inhibits cancer cells whereas normal cells remain unaffected. Depletion of BMI-1 by PTC-028 induces caspase-mediated apoptosis[1]. BMI-1[1]


PTC-028 (25-500 nM; 48 hours) significantly decreases CP20, OVCAR4 and OV90 epithelial ovarian cancer cells viability. However, in normal ovarian surface epithelial cells (OSE) and fallopian tube epithelial cells (FTE) cells, up to 500 nM treatment with PTC-028 for 48 hours has minimal effect (