INH14是IKKα/IKKβ的抑制剂，IC50值分别为8.97和3.59μM。INH14抑制IKKα/β依赖性TLR炎症反应。抑制TAK1/TAB1的下游和NF-kB信号通路。具有抗炎和抗癌作用。
CAS：200134-22-1
分子式：C15H16N2O
分子量：240.3
纯度：98%
存储：Store at -20°C

Background:

INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively. INH14 inhibits the IKKα/β-dependent TLR inflammatory response. INH14 also inhibits downstream of TAK1/TAB1 and NF-kB pathways. Anti-inflammatory and anti-cancer activity[1]. IKKβ|3.59 μM (IC50)|IKKα|8.97 μM (IC50)

INH14 (5 µg/g, i.p. for 2 hours) reduces lipopeptide-induced inflammation in mice[1]. Animal Model: 8-week old, male, pathogen-free C57BL/6J mice[1]

[1]. Drexel M, et al. INH14, a Small-Molecule Urea Derivative, Inhibits the IKKα/β-Dependent TLR Inflammatory Response. Chembiochem. 2019 Mar 1;20(5):710-717.