NSC185058是一种ATG4B抑制剂。ATG4B是一种主要的半胱氨酸蛋白酶(cysteineprotease)。NSC185058显著减弱自噬(autophagic)活性。
CAS：39122-38-8
分子式：C11H9N3S
分子量：215.27
纯度：98%
存储：Store at -20°C

Background:

NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. NSC185058 markedly attenuates autophagic activity[1]. ATG4B[1]Autophagy[1]

NSC185058 is an ATG4B antagonist. ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. Inclusion of the ATG4B inhibitor NSC185058 enhances the anti-tumor activity of radiation therapy (RT). NSC185058 decreases glioblastoma (GBM) cell tumorigenicity, and enhances the anti-tumor activity of RT when applied to orthotopic GBM xenograft models[1].

[1]. Huang T, et al. MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma. Cancer Cell. 2017 Dec 11;32(6):840-855.e8.