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Micafungin Sodium(FK 463)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Micafungin Sodium(FK 463)图片
CAS NO:208538-73-2
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)1292.26
FormulaC56H70N9NaO23S
CAS No.208538-73-2 (Micafungin Sodium);
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 100 mg/mL (77.4 mM)
Water: 100 mg/mL (77.4 mM)
Ethanol: <1 mg/mL
SMILESO=S(OC1=CC([C@H](O)[C@@H](O)C(NC(C2N(C(C(NC([C@]([H])(C[C@@H](O)[C@@H](O)NC(C3N(C(C([C@H](O)CC(N)=O)N4)=O)C[C@H](C)[C@@H]3O)=O)NC(C5=CC=C(C6=NOC(C7=CC=C(OCCCCC)C=C7)=C6)C=C5)=O)=O)[C@H](O)C)=O)C[C@H](O)C2)=O)C4=O)=CC=C1O)([O-])=O.[Na+]
SynonymsFK463 Sodium; FK 463 Sodium; FK-463 Sodium; Mycamine; FK-463
实验参考方法
In Vitro

In vitro activity: Micafungin is an antifungal agent known to inhibit 1,3-β-D-glucan synthesis in Candida albicans. In 13 out of 18 P. Aeruginosa isolates tested, micafungin significantly reduced biofilm biomass. In all 9 P. Aeruginosa isolates tested, micafungin decreased the expression of ndvB, which encoded the cell wall 1,3-β-D-glucan. Also, it decreased the expression of biofilm encoding genes for alginate and pellicles (algC and pelC, respectively).


Fungus experiment: Micafungin decreased the expression of biofilm encoding genes for alginate and pellicles (algC and pelC, respectively).

In VivoIn a mouse model of septic A. fumigatus infection, micafungin (0.1 mg/kg) increased the survival rate of mice to 20%. When micafungin (0.1 mg/kg) combination with KB425796-C (32 mg/kg), the survival rate of mice increased to 100% in the 31-day post-infection period. While non-treated mice survived for only 6 days.
Animal modelA mouse model with septic Aspergillus fumigatus (A. fumigatus) infection
Formulation & Dosage0.1, 0.32 and 1 mg/kg; s.c.; q.d.
ReferencesBiofouling. 2013 Sep;29(8):909-15; J Antibiot (Tokyo). 2013 Aug;66(8):479-84.