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Tirabrutinib hydrochloride(ONO-4059(hydrochloride))
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tirabrutinib hydrochloride(ONO-4059(hydrochloride))图片
CAS NO:1439901-97-9
规格:98%
分子量:490.94
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Tirabrutinib(ONO-4059)hydrochloride的IC50值是2.2nm,是一种有选择性和新颖的抑制剂。在B细胞中ONO-4058结合BTK,因此阻止B细胞受体信号和阻碍B细胞的发展。
CAS:1439901-97-9
分子式:C25H23ClN6O3
分子量:490.94
纯度:98%
存储:Store at -20°C

Background:

Tirabrutinib (ONO-4059) hydrochloride is a selective and novel inhibitor of BTK with IC50 2.2 nm, Tirabrutinib binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.




[1]. Akintunde Akinleye et al. Ibrutinib and novel BTK inhibitors in clinical development. J Hematol Oncol, 2013, 6: 59. [2]. Harriet S et al. A phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature B-cell malignancies. Blood 2016, 127:411-419.