SPP-86是一种选择性的、RET酪氨酸激酶的有效抑制剂，其IC50值为8nM。SPP-86能选择性的抑制RET诱导的甲状腺癌细胞中ERK1/2的磷酸化。
CAS：1357349-91-7
分子式：C16H15N5
分子量：277.32
纯度：98%
存储：Store at -20°C

Background:

SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM. SPP-86 selectively inhibits RET- induced ERK1/2 phosphorylation in thyroid cancer cell lines[1]. IC50: 8 nM (RET)[1].

[1]. Alao JP, et al. Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86. BMC Cancer. 2014 Nov 20;14:853.