Oleanonic acid (3-Oxooleanolic acid) 是一种三萜，可以抑制 HIV-1 对细胞的感染。起抑制 HIV-1 体外感染 PBMC，自然感染 PBMC和单核细胞/巨噬细胞的 EC50 分别为 22.7 mM，24.6 mM 和57.4 mM。除此之外，它可以抑制鼠腹腔白细胞产生白三烯 B4，IC50为 17 μM。
CAS：17990-42-0
分子式：C30H46O3
分子量：454.68
纯度：98%
存储：Store at -20°C

Background:

Oleanonic acid (3-Oxooleanolic acid) is a triterpenoid, inhibits infection by HIV-1 in in vitro infected PBMC, naturally infected PBMC and monocyte/macrophages with EC50 of 22.7 mM, 24.6 mM and 57.4 mM, respectively.

[1]. Giner-Larza EM et al.Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity.Eur J Pharmacol.Sep 28;428(1):137-43.doi:10.1016/S0014-2999(01)01290-0(2001) [2]. Fabio Mengoni.Anti-HIV Activity of Oleanolic Acid on Infected Human Mononuclear Cells.Planta Med 68(2): 111-114.DOI: 10.1055/s-2002-20256(2002)